Abstract: The process of"primary sedimentation tank-internal circulation reactor-intermediate sedimentation tank-A²/O （anaerobic/anoxic/aerobic）-secondary sedimentation tank-reaction tank-final sedimentation tank"was used to treat the wastewater of wine production,which has the capacity of 300 m³/d.The result showed that the process had good removal efficiency for COD,NH₃-N,TN and TP.The final effluent completely met the first standard of“integrated wastewater discharge standard in Shandong Peninsula basin”（DB 37/3416.5—2018） and the standard of the dry farming irrigation in the“farmland irrigation water quality standard”（GB 5084-2021）.It can be used for the irrigation of grape bases.The practical project proved that the process had many advantages,such as stable operation,low investment,low running cost and clear water effluent,and it also had good economic and environmental benefits.