Abstract: Tetracycline, a persistent organic pollutant, and antimony, a carcinogenic element, are increasing in the environment and can enter the food chain through the accumulation of plants, which would cause serious harm to human health. In this study, the effects of tetracycline, antimony and tetracycline and antimony on hepatopancreatic protein content, glutathione transferase (GSH) and catalase (CAT) activity were studied. The results showed that the pollutant reduced the protein content in the snail.The activity of GSH increased with the increase of exposure time and exposure concentration.CAT activity showed different correlations with exposure time and exposure conditions. Low concentration inhibition and high concentration promotion effects were observed under single exposure conditions, while the opposite effect was observed under combined exposure conditions.