Abstract: In this study, Urumqi was taken as the research object. The data was collected by fixed-point monitoring method and analyzed the spatial variation characteristics of air pollutants in the neighborhood. The effects of meteorological factors and morphological factors on pollutants were discussed. The results showed that the spatial distribution of NO₂ had a strong autocorrelation, and the spatial distribution of PM_2.5 was scattered, and NO₂ and PM_2.5 had a significant correlation with meteorological factors. Building density, height, and floor area ratio were positively correlated with pollutants, while sky sight shed factor was negatively correlated, and road density was also positively correlated with pollutants.