Abstract: Based on the current consumptions of VOCs raw and auxiliary materials used in investigated enterprises. The emission factor method was used to estimate the VOCs emissions of packaging and printing industry in a city of Yunnan. Packaging and printing enterprises with VOCs emissions more than 20 t was selected and analyzed in the city; a typical enterprise was chosen to analyze the emissions reduction of waste VOCs. The results showed that the VOCs amount emitted from packaging and printing industry in the city was 4060.01t in 2021. According to the typical enterprise transformation program, packaging and printing enterprises with emissions greater than 20 t in the survey area could reduce 949.98 t VOC emissions. Large enterprises should optimize the process control and end-of-pipe treatment technology, small enterprises should optimize the type and quality of raw and auxiliary materials used involving VOCs, would be the best choice to control the investigation of regional packaging and printing industry VOCs emission reduction.