Abstract: A three-dimensional numerical simulation was conducted using ASU House as the site case, and the Darcy's law and the law of dilute matter transfer in porous media were used to simulate the soil gas velocity field and the flux of VOCs into the building,so as to obtain the spatial and temporal distribution law of VOCs in the stratum under negative pressure conditions. The results showed that the pollutant concentration increases significantly under the negative pressure condition and the vapor intrusion process was enhanced compared with the baseline condition. The closer the distance from the negative pressure center to the pollution source,the higher the pollutant concentration was.